Archive for December, 2007

Herpes Zoster - Risk Increases With Rheumatoid Arthritis and DMARD Use

Sunday, December 30th, 2007

Herpes zoster, or shingles, is caused by the same virus that causes chickenpox. Following chickenpox, the virus becomes dormant in the body but herpes zoster can emerge again years later. Reactivation of the virus has been linked to aging, stress, or an impaired immune system. According to a study published in the December 15, 2007 issue of Arthritis Care & Research, researchers attempted to determine if the incidence of herpes zoster is elevated in rheumatoid arthritis patients and if the use of disease-modifying anti-rheumatic drugs (DMARDs) contributes to an increase in herpes zoster.

Using two large databases, researchers compared the rate of herpes zoster among 160,893 rheumatoid arthritis patients and randomly selected non-rheumatoid arthritis patients. Researchers concluded that patients with rheumatoid arthritis are at increased risk of herpes zoster. Also, current use of DMARDs (biologic DMARDs and traditional DMARDs) was tied to an increased risk of herpes zoster, as was the use of oral corticosteroids.

Source: Herpes Zoster - Risk Increases With Rheumatoid Arthritis and DMARD Use

Burning Bush Home [Greg Laden’s Blog]

Sunday, December 30th, 2007

President Bush’s boyhood home was severely damaged by a fire.I nvestigators in Odessa now believe an arsonist is to blame.

[source]

Burning Bush Home

Source: Burning Bush Home [Greg Laden’s Blog]

The Wrong Way to the Correct Conclusion [Dr. Joan Bushwell’s Chimpanzee Refuge]

Saturday, December 29th, 2007

Astrology. Classic woo. Not much to say about it other than the fact that for some very strange reason a lot of people still believe in it, at least a little. Maybe it’s because almost every newspaper in the country still has an astrology column. I don’t know. For the sake of my students, several years ago I wrote a little analysis on astrology and why it’s utter bullshit. You can find it here. To be blunt, no one should put any stock in astrology.

Today I stumbled across an explanation of why astrology is to be ignored, but from a completely different perspective, namely that of the fundamentalist Christian nut-job. This delicious bit of woo reaches essentially the same conclusion (ignore astrology) but does so in a most bizarre fashion. The basic argument is that the purpose of astrology is to gain knowledge of the future. According to the author, god and the bible declare that information to be off limits for humans. Consequently, “good Christians” should not make use of astrology. The argument has nothing to do with the efficacy of astrology or its supposed mechanism. In other words, even if it works, you shouldn’t do it because it will upset god’s plan. Interesting logic, eh?

See? Who says science and religion can’t agree on some things?

Source: The Wrong Way to the Correct Conclusion [Dr. Joan Bushwell’s Chimpanzee Refuge]

Top ten issues in hospital medicine for 2007, issue 3: does the hospitalist model of care improve efficiency and outcomes?

Saturday, December 29th, 2007

Two papers in 2007 weighed in on this debate. First was this study from the Archives of Internal Medicine showing a statistically significant reduction in length of stay (5.01 vs 5.87 days) associated with an academic hospitalist model in comparison with non-hospitalist care at Albert Einstein College of Medicine.

Just out is this paper from NEJM comparing hospitalitalist care with that of non-hospitalist internists and family practitioners. Hospitalist care was associated with a shorter length of stay than traditional care by internists and FPs (0.4 days for both comparisons), a reduction in cost per case of $268 compared with traditional internal medicine care and no significant difference with family practice care. (Maybe that means family practitioners order fewer or less expensive tests than internists).

How can we interpret these results in light of what was already known? There have been too many papers for me to link here, so I’ll offer an oversimplified timeline. Early in the movement, small studies suggested that the hospitalist care model was associated with reduced charges and length of stay. A study presented at the 2005 meeting of the Society of Hospital Medicine, however, burst the bubble. That largest to date study showed no superiority of hospitalist care in terms of outcomes or efficiency. To my knowledge that was the largest study conducted until the NEJM study linked above. Bob Wachter, commenting on the Archives paper, said there were more than 20 studies with results favoring the hospitalist model. (I didn’t know there were that many!).

From the varied blog reactions to the NEJM paper it seems there are a gazillion ways to interpret the evidence. Dr. Wes is skeptical of the results, seems to question the meaning of $268 per case and laments the discontinuity of care that is built into the hospitalist model. The Happy Hospitalist has a happier spin, doing a little math to suggest how $268 per case translates into real money over multiple admissions and comments on some intangible benefits of hospitalist care. Retired Doc offers a nice summary of the blog reactions here and concludes with perhaps the only statement we can all agree on: the hospitalist movement is here to stay. Bob Wachter weighed in here (did I miss anybody?).

Wachter has some interesting observations on how the fallout from this study may affect the hospitalist looking for a job or jockeying for better compensation. As I see it, it could play out in any number of ways. Wachter suggests that this study, which shows a smaller resource saving than some older studies, could prompt hospital administrators to tighten their budgets for hospitalist compensation:

Since most hospitalist groups get (and require) hospital support, and much of that support has been predicated on a Return-on-Investment drawn from earlier findings of 15 percent LOS and cost reductions, expect some skirmishes at budget time, with hospitals trying to tighten the screws on their hospitalist groups (“why should we raise your support – you only save us $200 per patient!”).

But I could see it play out another way. Given that the economic value of the hospitalist model was in dispute at least in the minds of some, administrators who look at this paper as having settled the issue once and for all may now say “Hospitalist care is supposed to save money. Why aren’t you doing better than your non-hospitalist peers?”

No matter how you slice it, you’re better off if you can convince folks that there are non-economic and intangible benefits of hospitalist care. As Wachter said,

The hospitalist group that has not convinced its CFO that the true ROI doesn’t hinge on pure cost reduction – but rather on systems improvement, QI, patient safety, and more – may be in for a bumpy ride.

Source: Top ten issues in hospital medicine for 2007, issue 3: does the hospitalist model of care improve efficiency and outcomes?

Massachusetts physicians, families to ?Make a Difference? on October 25

Saturday, December 29th, 2007

Waltham, Mass. ? Sept. 16, 2003 ? Massachusetts physicians and their families will fan out across the state on Saturday, October 25, as they volunteer to help those affected by domestic violence.
   

The Massachusetts Medical Society Alliance and the Massachusetts Medical Society & Alliance Charitable Foundation are sponsoring the first annual ?Physicians and Their Families Make a Difference Day,? conducted as part of the national ?Make a Difference Day? coordinated by USA Weekend Magazine and the Points of Light Foundation.
   

The statewide effort will focus on securing comfort items for families in local shelters for domestic violence.
   

Vanessa P. Kenealy, president of the Massachusetts Medical Society Alliance, said that a great need persists for items that most of us take for granted.
   

?Survivors of domestic violence often flee their homes on a moment?s notice,? said Kenealy. ?They leave a lot behind, and our effort is to try to make their time at the shelter more comfortable.?
   

An attorney and Hopkinton resident, Kenealy is enlisting volunteers to distribute and pick up donation bags in communities and neighborhoods across the state. The volunteers will distribute the bags during the first week in October, and then return on or about October 25 to pick up the filled bags, which will then be delivered to shelters across the state
   

The physicians and their families seek personal care and comfort items such as combs, shampoo, toothpaste and toothbrushes, baby food and formula, disposable diapers, socks and undergarments for adults and children, children?s books and magazines, feminine products, and small luxuries such as nail polish and lip gloss.
   

Kenealy, noting that most guests at shelters are women and children, encourages everyone to make a donation to the cause, saying ?every gift, large or small, does indeed make a difference to those forced to stay in a shelter.?
   

For more information on ?Physicians and Their Families Make a Difference Day,? contact Jennifer Day, program manager, at 781-434-7044 or jday@mms.org.
   

For information on the Medical Society?s Campaign Against Domestic Violence, with listings for hotlines and services available, visit www.massmed.org/pages/dv_campaign.asp
   

The Massachusetts Medical Society Alliance is the organization of physicians? spouses committed to advancing the health and well being of the medical family. In conjunction with the Massachusetts Medical Society, the Alliance advocates and promotes good health among the citizens of the Commonwealth of Massachusetts
   

The Massachusetts Medical Society and Alliance Charitable Foundation is a supporting organization of the Massachusetts Medical Society and the MMS Alliance. Since its inception, the Foundation has made more than $330,000 in allotments, supporting such services as medical care for the uninsured and underserved, childhood injury prevention, and rape crisis and services for battered women.
   

The Massachusetts Medical Society, with more than 18,000 physicians and student members is dedicated to educating and advocating for the physicians and patients of Massachusetts. Founded in 1781, the MMS is the oldest continuously operating medical society in the country. The Society owns and publishes The New England Journal of Medicine, the Journal Watch family of professional newsletters, AIDS Clinical Care, and produces HealthNews, a consumer health publication. For more information, visit www.massmed.org.

Source: Massachusetts physicians, families to ?Make a Difference? on October 25

Weird Furry Orangina Advertisement [Omni Brain]

Saturday, December 29th, 2007

This is one odd video. This French Orangina TV ad has furries wearing kinky lingerie and an octopus giving a lap dance to a bear.

Check it out:

I guess I shouldn’t be surprised after this previous post about a French set of ads on safe sex practices.

-Via BoingBoing-

Source: Weird Furry Orangina Advertisement [Omni Brain]

This Shirt Is Awesome [Shifting Baselines]

Saturday, December 29th, 2007

Another great product from Despair, Inc.

Source: This Shirt Is Awesome [Shifting Baselines]

A tax on gorilla iconography? Oh noes… [Evolving Thoughts]

Friday, December 28th, 2007

Greg Laden is reporting that Rwanda is taxing companies that use gorillas in their advertising, in order to pay for their conservation. Unfortunately, or fortunately if you are an albino silverback in Australia, this only applies to Rwandan companies. Or maybe I would happily pay a tax to the Rwandan government for the use of my avatar if asked. It depends on whether I have enough money for beer that month.

Source: A tax on gorilla iconography? Oh noes… [Evolving Thoughts]

Cancer stem cells may be at the root of brain tumors

Friday, December 28th, 2007
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Stem cells — popularly known as a source of biological rejuvenation — may play harmful roles in the body, specifically in the growth and spread of cancer. Amongst the wildly dividing cells of a tumor, scientists have located cancer stem cells.

Physician-scientists from Weill Cornell Medical College are studying these cells with hopes of combating malignant cancers in the brain.

“Some patients’ brain tumors respond to chemotherapy and some don’t,” says Dr. John A. Boockvar, the Alvina and Willis Murphy Assistant Professor of Neurological Surgery and head of the Brain Tumor Research Group at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. “We believe cancer stem cells may be the cause.”

Dr. Boockvar is capturing and classifying these cancer stem cells in order to determine how they react to certain available drug therapies. Doing so will lead to more accurate and specific cancer diagnosis, allowing for tailored drug treatments. Results explaining the techniques used to harvest normal neural and brain-tumor-derived stem cells will be described in the January 2008 edition of the journal Neurosurgery.

“Cataloging brain tumor stem cells will be an enormous tool for patient diagnosis,” explains Dr. Boockvar, “but it will also help to create a library of knowledge for the scientific community to understand how brain tumors form and to test and develop new drugs.”

To stave off cancer stem cell growth in the brain, Dr. Boockvar is studying the use of two drugs already available for cancer treatment. Tarceva — approved for the treatment of lung and pancreatic cancer — works by stopping the growth and spread of cancer cells. Avastin — approved for the treatment of colorectal cancers — is also being studied for inhibiting cancer cell growth and works by stopping the growth of blood vessels (angiogenesis) that feed the tumor.

Preliminary results from these trials have shown that some patients’ cancers are wiped out, whereas others remain resistant. Dr. Boockvar believes that these patients’ drug resistance might be due to a class of stem cells resilient to available treatments. Finding biomarkers that distinguish these stem cells from those that are destroyed by known drugs might help researchers formulate new drugs.

“Determining a patient’s cancer stem cell profile will take a lot of the guessing out of choosing a course of treatment,” says Dr. Boockvar. “It will save money, medical resources and precious time for the patient.”

Source: Cancer stem cells may be at the root of brain tumors

Public notice

Friday, December 28th, 2007

Dear General Public,

It is getting to be the end of the year. Your local community pharmacy is bristling with business. Between the increased volume due to respiratory ailments and people trying to get one last refill in before their insurance changes on January 1, things are very busy. Sometimes the pharmacy staff can be a little short with you because we’ve had people bitching about this, that, and the other all day long.

So when you call in a refill over the automated system and come in and pick it up, then call me after you get home to see if you can return it and fill it after January 1, don’t expect me to bend over backwards for you. It is not legal for me to take medication back once it has the the physical confines of the pharmacy.

Your lack of planning is not my fault. If you would have planned ahead, you would have asked me to fill enough tablets to get you thru until about the third of January, then refilled your prescription normally once your new plan year has started. I didn’t choose your sucky insurance plan, so don’t get pissy with me.

And when you come back to the pharmacy to make a scene, please brush your teeth beforehand. Or at least use a breath mint or chew a piece of gum. Your ass-breath is not that appealing to me. Or your body odor.

When you storm away from the counter, it is not necessary for you to say “Thanks for nothing” and announce that you won’t be returning to my pharmacy. Because you will. And it will probably be within the next 10 days. You only wait about 10 minutes to have your prescription filled at Pharmacy God Pharmacy. Once you go to my competitor and have to wait 45 minutes to find out that your prescription is too soon to be refilled, you’ll be back.

And I’ll forgive you for being a total ass/bitch.

Because I am a forgiving Pharmacy God.

Source: Public notice